The Sanctum of Domination raid takes place in Torghast where players defeat nine bosses as they climb the tower, and finally encounter Sylvanas Windrunner at the top.

• The Tarragrue
  The Jailer's relentless beast, the Tarragrue, has stalked the halls of Torghast since its first spire was raised. Countless victims have felt their souls trampled to ash by this monstrosity, which now awaits the mortal champions breaching the threshold of the tower.

• Eye of the Jailer
  When Azeroth was young, Odyn traded his eye to Mueh'zala to peer into the Shadowlands. Vain Odyn was deceived, for the Jailer twisted the Eye to serve his own ends. The Eye's unwavering gaze allows the Jailer to see all that transpires within his domain--and perhaps others as well.

• The Nine
  The dark pact Sylvanas struck with the val'kyr forged her bond with the Jailer. Through the years, these winged sisters faithfully served the Dark Lady, even if it meant sacrificing themselves on her behalf. Now Sylvanas calls her nine val'kyr to fight for her one last time.

• Remnant of Ner'zhul
  Intended to herald the Jailer's reign on Azeroth, the first Lich King, Ner'zhul, proved unworthy in his master's eyes. The last remnants of the fallen orc's twisted soul were encased in spiked shadowsteel, condemned to everlasting torment for his failure. All who cross his path will share in his suffering.

• Soulrender Dormazain
  Soulrender Dormazain extracts anima from the hellaciously brutish captives of Torghast to fuel the Jailer's armies. The tormentor has never met a soul he couldn't break, but his latest victim is proving resistant to the usual methods. Feeding on this captive's unending rage, Dormazain will enjoy spending millennia finding his weaknesses.

• Painsmith Raznal
  Painsmith Raznal is a sadistic mastermind who spent eons perfecting the deadly traps found in Torghast. He relishes the screams of his victims as a testament to his skill, listening with malignant delight as they echo through the tower's desolate halls.

• Guardian of the First Ones
  Pulled by the Jailer's chains from a distant, unknown realm, this malfunctioning guardian seeks to protect the inscrutable knowledge known as "cyphers". It uses the last of its power to obliterate any who would attempt to plunder the secrets of its enigmatic makers.

• Fatescribe Roh-Kalo
  Once a fatescribe entrusted with Korthia's countless secrets, the Mawsworn seized Roh-Kalo and bound him to the Jailer's will. With Torghast's power at his disposal, Roh-Kalo seeks to author a new fate for the Shadowlands.

• Kel'Thuzad
  The nefarious Kel'Thuzad awaits at the apex of the soul river, allowing the lich to draw upon an unlimited well of power. All his countless schemes and machinations have led to this final confrontation, where he has plotted the mortal champions' ultimate demise in service of his true master.

• Sylvanas Windrunner
  With Oribos in peril, a desperate battle at the pinnacle of the Sanctum begins. Standing between the Jailer and the mortals who would stop him is Sylvanas Windrunner. With no masks left to wear, the Banshee Queen unleashes her full power to protect the Banished One while his ultimate plan unfolds.